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Health and Security IV

Prof. Shoichi Ishiura


Health, aging and Alzheimer's disease

    Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by extracellular deposits of amyloid-b peptide (Ab) in brain. Ab is generated from the amyloid precursor protein (APP), a large type I transmembrane protein, and is cleaved out by two proteolytic enzymes termed b- and g-secretases. This course provides biochemical overview of the aging of brain, especially in genetic and environmental aspects. 



Brain structure 


History of the neuroscience


Molecular mechanisms of senile plaque formation







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