The University of Tokyo, GPES

Our Courses

• Our Courses
• Research
  • Research Areas
• Lecture Courses
  • Course List
  • Foundations of Environmental Sciences I
  • Environmental Management and Policy I
  • Environmental Measurement and Evaluation IV
  • Environmental Measurement and Evaluation VI
  • Materials Systems and Dynamics I
  • Materials Systems and Dynamics II
  • Materials Systems and Dynamics IV
  • Energy Technology and Natural Resources I
  • Energy Technology and Natural Resources III
  • Health and Security I
  • Health and Security III
  • Health and Security IV
  • Health and Security II
  • Health and Security V
  • Environmental Measurement and Evaluation II
  • Materials Systems and Dynamics V

Health and Security IV

Prof. Shoichi Ishiura

Health, aging and Alzheimer's disease

    Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by extracellular deposits of amyloid-b peptide (Ab) in brain. Ab is generated from the amyloid precursor protein (APP), a large type I transmembrane protein, and is cleaved out by two proteolytic enzymes termed b- and g-secretases. This course provides biochemical overview of the aging of brain, especially in genetic and environmental aspects. 

・Brain structure 

・History of the neuroscience

・Molecular mechanisms of senile plaque formation

・Senescence

・Food/Antioxidants

・Excercise